9 Lee Lee C C Zeng Zeng J J Drew Drew BG BG Sallam Sallam T T Martin-Montalvo Martin-Montalvo A A Wan Wan J J et al et al The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance Cell Metab Cell Metab 2015 2015 21 21 3 3 443 443 454 454 10.1016/j.cmet.2015.02.009 10.1016/j.cmet.2015.02.009 25738459 25738459. The gene discussed is INS; the disease is obesity disorder.