NFKB1 and Parkinson disease: For example, calycosin attenuates 1-Methy-l-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD by inhibiting the activation of TLR/NF-κB and MAPK pathways20; polyphenols from Toona sinensis seeds alleviate neuroinflammation induced by 6-hydroxydopamine through down-regulating p38 MAPK signaling pathway in PD rats21.