PTS and colorectal cancer: The overexpression of LTBP1 in ovarian cancer results in distribution of TGF-β1 in the stromal tissue surrounding carcinoma cells (11), and in colorectal cancer, protein tyrosine phosphatases (PTPS) facilitate iNOS-mediated LTBP1 S-nitrosylation and LTBP1 protein degradation, thereby promoting the development of early colorectal cancer (12).