LTBP1 and cancer: As tumor metastasis accounts for most cancer-related deaths and low expression of LTBP1 in tumor cells highly promotes metastasis in vivo, we injected HELA LTBP1 shRNA or HT-3 LTBP1 shRNA cells into the tail vein of nude mice, after which mice were intraperitoneally injected with carboplatin (10 mg/kg).