PPARA and neoplasm: Therein, it was shown that HFPO-DA is not genotoxic, but induced cancers in Sprague Dawley rats in a pattern consistent with the PPARα tumor triad of liver adenomas/carcinomas, testicular Leydig cell tumors and pancreatic acinar cell tumors (Corton et al., 2018; Felter et al., 2018; Klaunig et al., 2003).