Examples of genes with altered dynamics included increased levels of genes with a negative role in erythropoiesis such as JUN and YBX1 (Bhullar and Sollars, 2011; Lee et al., 2014) and NME4, previously associated with poor prognosis in MDS (Kracmarova et al., 2008). Here, YBX1 is linked to myelodysplastic syndrome.