XDH and colorectal carcinoma: CRC showed a variety of specificities in the abovementioned results; we, therefore, selected six CRC‐dysregulated metabolic rate‐limiting enzymes (IMPDH1, MYLK, XDH, DPYD, UGDH and PTGS1) for validation in our clinical cohort by qRT‐PCR assays (Figures 5A, S2A and Table S4).