Moreover, 4 DFMGs (ALDH2, ACACB, ACOX2 and FBP1) and 11 UPMGs (DTYMK, IMPDH1, PYGL, SCD, SQLE, LDHA, PKM, PLAU, TK1, G6PD and RRM2) were present in at least 5 cancer types, and these 15 enzymes were also APMG or AFMG in at least 1 cancer type (Figure 3B), which suggests tumour specificity and functional conservation of these metabolic rate‐limiting enzymes. This evidence concerns the gene PKM and neoplasm.