Given the correlation between Myc and metabolic rate‐limiting enzymes (Figure 4) and the relationship between Myc and IMPDH1 or IMPDH2 in CRC cell lines (Figure S3H), we hypothesized that Myc promotes de novo GTP biosynthesis by regulating the expression of IMPDH1 and IMPDH2 in CRC. The gene discussed is IMPDH2; the disease is colorectal carcinoma.