For example, hyperglycemia-induced oxidative stress, inflammatory response, protein kinase C activation, and upregulation of vascular endothelial growth factor (VEGF) lead to retinal vascular value-added lesions, vitreous hemorrhage, retinitis, and even retinal detachment (Dong et al., 2009; Cheung et al., 2010). The gene discussed is VEGFA; the disease is retinal detachment.