[44] Invasin, a 986‐amino acid protein anchored to the outer membrane and encoded by the gene inv, promotes uptake into host‐cells by binding to β1‐integrins and stimulating Rac‐1.[45] As a proof of concept of the therapeutic potential of our synthetic biology chassis, we created Cyborg E. coli BL21(DE3) Cells expressing Invasin and mOrange (Methods Section M1, Figure S14, Supporting Information) and tested if the Cyborg Cells could invade cancer‐derived cell lines SH‐SY5Y (neuroblastoma) and HeLa (adenocarcinoma) (Figure 5B–G, Methods Section M14&M15). This evidence concerns the gene RAC1 and adenocarcinoma.