FGF2 and breast carcinoma: Other serum biomarkers studied in their breast cancer prevention studies were urinary plasminogen activator and basic fibroblast growth factor, all of which had similar positive correlations with breast cancer. They also noted that women with high BMIs under 45 are likelier to have ER-aggressive tumors than their thinner age-matched cohorts and that women who gain weight after menopause are more likely to develop estrogen/progesterone (ER/PR)-positive breast cancer than ER/PR-negative breast cancer [24].