BDNF and cardiovascular disorder: Statins may have potential therapeutic implications in patients with an abnormality in the tPA-plasminogen pathway or other comorbidities relating to cardiovascular disease [20]. Furthermore, Atorvastatin treatment resulted in increased serine/threonine protein kinase (Akt) phosphorylation, synaptic-related protein synapsin, brain-derived neurotrophic factor (BDNF), and spinophilin expression [26].