The National Wilms' Tumor Study Group (NWTS) found that Wilms' tumor is related to genetic alternations that are responsible for normal embryological development, a mutation in the Wilms' tumor 1 (WT1) gene leads to developmental abnormalities in the renal and genitourinary tract, and Wilms' tumorigenesis, causing several syndromes such as Denys-Drash and WAGR syndromes [46]. This evidence concerns the gene WT1 and Nephroblastoma.