The co-occurrence of HER2 mutations and amplification has been associated with poor response to trastuzumab and lapatinib, although neratinib has been shown to be effective against HER2-positive, HER2-mutant preclinical models and in patients whose breast tumors had coincident HER2 amplification and mutation, suggesting neratinib as monotherapy may be effective in this setting[27]. Here, ERBB2 is linked to breast neoplasm.