It has been demonstrated that the inhibition of ALDH activity by all-trans retinoic acid (ATRA) or the specific ALDH inhibitor diethylaminobenzaldehyde in breast CSCs (BCSCs) significantly increases the efficacy of doxorubicin, paclitaxel, and radiotherapy on triple-negative breast cancer (TNBC) cells[186]. This evidence concerns the gene LDHA and triple-negative breast carcinoma.