In their analysis of the association of genome-wide CNA in breast cancer tissues of HER2-positive breast cancer patients who received trastuzumab, lapatinib, or both, with response to anti-HER2 treatment, Guarneri et al. reported that, unlike pCR patients, non-pCR patients showed a CNA signature[48]. The gene discussed is ERBB2; the disease is breast carcinoma.