In addition, cell cycle regulators such as p21/Waf1, CYCLIN D1 (CD1) and CD3, and an important regulator of stem cell biology (c-Myc), an EGFR-related gene found to be amplified in human breast cancer cell lines such as the human epidermal growth factor receptor 2 (HER2), as well as nuclear factor kappa B (NF-κB), insulin-like growth factor 1-receptor (IGF1-R), survivin, snail homolog 2 (SLUG), SOX2, and paired box (PAX) 5[19,20], all directly associated with tumorigenesis, are described as Notch target genes[20,21]. The gene discussed is IGF1R; the disease is breast cancer.