SYK and precursor B-cell acute lymphoblastic leukemia: Notably, a nanomedicine candidate containing the SYK-inhibiting small molecule compound 1,4-bis(9-O-dihydroquinidyl) phthalazine/hydroquinidine1,4-phathalazinediyldiether (C61) was capable of destroying > 99.9% of clonogenic B-ALL cells in vivo and thereby improved the event-free survival outcome of SCID mice challenged with otherwise invariably fatal doses of human leukemic B-cell precursors in each of three different xenograft models of chemotherapy-resistant human B-ALL[62].