We compared the transcriptomes of primary leukemic cells from KMT2A/MLL-R+vs. KMT2A/MLL-R- AML and ALL patients with an emphasis on the relative gene expression levels of for 21 PTK, including ERBB1, FGR, FLT3, FYN, HCK, JAK2, LCK, LYN, MERTK, SRC, BLK, BMX, BTK, ERBB2, ERBB3, JAK1, JAK3, PTK2, SYK, TEC, TYK2. Here, BTK is linked to acute lymphoblastic leukemia.