In infants [Figure 1; Supplementary Table 4], children [Figure 2; Supplementary Table 5] and adults [Figure 3; Supplementary Table 6] with KMT2A/MLL-R+ ALL, the gene expression levels for FLT3, BTK, SYK, JAK2/JAK1, as well as several SRC family PTK, including BLK, were differentially and significantly amplified. Here, SYK is linked to acute lymphoblastic leukemia.