In the two genomic instability syndromes caused by mutations in non‐SMC elements of SMC5/6, the NSMCE2 mutations cause primordial dwarfism, extreme insulin resistance and gonadal failure,4 whereas the NSMCE3 mutations lead to lung disease immunodeficiency and chromosome breakage syndrome in early childhood.5 This evidence concerns the gene NSMCE2 and Insulin resistance.