The first study implying the link between gut microbiota and glioma dated back to 2016 when Kim et al. showed that the gut microbiota‐derived metabolite, compound K, decreased phosphorylation of PKCα and ERK1/2, expression of MMP9 and MMP2, and subsequent cell migration in glioma cells.86 The gene discussed is MMP2; the disease is central nervous system cancer.