While the mechanisms are not completely understood, activation of CAR-T cells is thought to result in the release of IFN-γ, TNF-α, and other inflammatory cytokines that drive macrophage and monocyte release of IL-6 and other cytokines, which may precipitate CRS and ICANS events via endothelial damage [13]. The gene discussed is IL6; the disease is congenital rubella syndrome.