Identified gene expression signals below the pSuggestive < 1e−05 (N = 297) were mapped to 175 unique genes and were involved in 32 significant pathways (p-values <0.05), including type II diabetes mellitus, insulin signaling, sphingolipid signaling, growth hormone synthesis, secretion and action, immune system, and nervous system development pathways (Additional file 2: Table S8). The gene discussed is INS; the disease is type 2 diabetes mellitus.