We observed for the first time that GCKR genotype rs1260326 for CC and TFAP2B genotype rs2206277 for CT were associated with TB in lean subjects, in which addition we found that GCKR genotype rs1260326 for TT was associated with TB in overweight recipients and FTO rs1421085 for CC was associated with TB in obese participants. Here, GCKR is linked to tuberculosis.