PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Genetic studies have shown that sterol regulatory protein binding factor (SREBF), transmembrane superfamily member 2 (TM6SF2), cholesteryl ester transfer protein, apolipoprotein C3 (APOC3), and patatin-like phospholipase domain-containing 3 (PNPLA3) have a promising contribution to the development and long-term prognosis of NAFLD in obese and lean individuals [43].