Hitherto, the best-known NAFLD inherited components are represented by single nucleotide polymorphisms (SNPs) in genes regulating hepatic lipid accumulation and metabolism, among which FTO alpha-ketoglutarate dependent dioxygenase (FTO) [14], transcription factor AP-2 beta (TFAP2B) [15], TBC1 domain family member 1 (TBC1D1) [16], glucokinase regulator (GCKR) [17], and potassium inwardly-rectifying channel subfamily J member 11 (KCNJ11) [18] have been evaluated as genetic determinants of NAFLD. The gene discussed is TBC1D1; the disease is metabolic dysfunction-associated steatotic liver disease.