It was discovered that 70% ethanol extracts of PCL (0.5 g/kg) could significantly improve spatial learning memory impairment in APP/PS1 mice, and its mechanism may be related to the increased expression of ER α, ER β, follicle-stimulating hormone receptor (FSHR) and luteinizing hormone receptor (LHR), which is expected to become a new drug against Alzheimer’s disease [117]. This evidence concerns the gene LHCGR and early-onset autosomal dominant Alzheimer disease.