Chowdhury et al. [121] showed that imperatorin (5, 10 mg/kg) pre-treatment significantly decreased levels of the pro-inflammatory cytokines TNF-α and IL-6, increased levels of brain-derived neurotrophic factor (BDNF), and reduced levels of oxidative stress and acetylcholinesterase (AChE) in the hippocampus and cerebral cortex of mice, reversing LPS-mediated cognitive impairment and neuroinflammation. Here, BDNF is linked to Cognitive impairment.