IL4 and pneumococcal infection: In the future, we will resolve the mentioned limitation and also analyze the profile of subclasses of specific IgG1 and IgG2a against PspA1-5c+p construct immunization, levels of the IL-4 and IFN- γ cytokines, and the protection ability of this construct in immunized groups against pneumococcal infections to confirm our computational immune simulation results.