Based on these functions, a Rag2 deficiency is associated with various diseases, such as severe combined immunodeficiency (SCID), Omenn syndrome (OS), atypical SCID (AS), delayed onset combined immunodeficiency with granulomas and autoimmunity (CID-G/AI), and other delayed-onset atypical presentations [6]. Here, RAG2 is linked to severe combined immunodeficiency.