Especially, upregulation of USP22 can remove the conjugated ubiquitin chain of Sirt1, therefore reducing the degradation of Sirt1 protein mediated by ubiquitin in hepatocellular carcinoma (Xiong et al. 2017); A previous study has revealed that USP22-mediated Sirt1 signaling is involved in the tumorigenesis (Xu et al. 2018); Moreover, the binding sites of miR-206 with USP22 have been forecasted by bioinformatics. Here, USP22 is linked to hepatocellular carcinoma.