KLF3 and brain infarction: Significant cerebral infarction was observed in MCAO mice, furthermore, compared to that in MCAO, Exo or Exos-Vector groups, the infarct volume in Exo-KLF3-AS1 group was reduced (Fig. 1D), indicating that exosomal KLF3-AS1 could optimally alleviate cerebral I/R injury in vivo.