These analyses also revealed that high expression levels of NFE2L2 could significantly increase the immune infiltrating levels of exhausted T cells, macrophages, monocyte cells, NKT, Tfh, Th17, Th2, and nTreg cells, especially of macrophages (Cor. = 0.46) and nTreg cells (Cor. = 0.26), while passive tie was detected for levels of CD8 naïve T Cells (Cor. = −0.37), B cells (Cor. = −0.35), CD4 naïve T cells and Gamma delta T cells in GBM (Fig. 5A, Fig S3A). Here, CD4 is linked to glioblastoma.