The mean ALT level in 8 studies19,30–32,34–36,42 was 26 IU/mL, and the pooled rate of significant liver fibrosis for studies with ALT level < 26 IU/mL (8%; 95% CI 0.02–0.25) was slightly lower than that for studies with ALT level > 26 IU/mL (16%; 95% CI 0.09–0.26), albeit without statistically significant difference. The gene discussed is GPT; the disease is Hepatic fibrosis.