In support of this hypothesis, IHC staining of paraffin tumor sections showed reduction of PD-L1+ cells, but increased infiltration of CD8+ T cells and granzyme B secretion in Atad3a-deficient tumors, with no changes in the number of Ki67+ tumor cells (Fig. 5c, d; Supplementary information, Fig. S7g). The gene discussed is CD8A; the disease is neoplasm.