Additionally, we reveal that ATAD3A, a negative regulator of PINK1-dependent mitophagy, prevents PD-L1 distribution at mitochondria and degradation, thus providing new insight into mitochondria-mediated PD-L1 protein homeostasis regulation in tumor immune microenvironment (Supplementary information, Fig. S10). The gene discussed is ATAD3A; the disease is neoplasm.