VEGFA and neoplasm: The results presented that the expression of vascular endothelial growth factor (VEGF) and insulin-like growth factor (IGF-1) mRNA decreased from 1.02 ± 0.16 to 0.82 ± 0.13, and 1.05 ± 0.13 to 0.81 ± 0.10, respectively, after the addition of cactus extract of 20 g/L, which helped to prevent tumor proliferation and expansion; However, the expression level of transforming growth factor (TGF-β) mRNA has increased from 0.98 ± 0.13 (control) to 1.77 ± 0.11 (cactus extract).