SOX2 and neoplasm: For example, the proportion of mice with DNp63+ tumor cells increase over time, with 33% at 4 weeks post induction and 100% at 12 weeks in the Rosa26LSL-Sox2-IRES-GFP;Nkx2-1flox/flox; Lkb1flox/flox (SNL) mouse model.65 They point out that NKX2-1 loss accelerates adeno-to-squamous transdifferentiation.