Moreover, Gupta et al. recently provided evidence that therapeutic overexpression of QKI is beneficial in a mouse model of doxorubicin-mediated heart failure.18 They showed that adeno-associated virus serotype 9 (AAV9)-mediated overexpression of QKI attenuates apoptosis and atrophy of cardiomyocytes in this model. This evidence concerns the gene QKI and heart failure.