ITIH4 and hydrops fetalis: Among these proteins, we found members of the ITIH family, namely, ITIH1, ITIH2, ITIH4 (AS), and ITIH4 (MR), which function as ECM stabilizers (Fig 6A), and fibronectin (FN1) (AS) (Fig 6A), which plays a prominent role in fibrosis and cardiac function according to an HF animal model (Valiente-Alandi et al, 2018).