Although plasma NfL increased in PMC compared to NC, this occurred much closer to onset in our dataset compared with the results from longitudinal data collected in the large Colombian PSEN1 p.E280A ADAD cohort and the results from the international collaborative Dominantly Inherited Alzheimer Network (DIAN) cohort.31–33 Also, we found that plasma NfL did not correlate to CSF core Alzheimer's disease biomarkers. Here, NEFL is linked to Alzheimer disease.