Patients with severe hemophilia A (factor VIII activity [FVIII:C] <1 IU/dL) typically experience spontaneous bleeds, primarily into joints.1Over time, repeated bleeds into the same joint trigger progressive damage that can develop into hemophilic arthropathy, resulting in pain, deformity, and disability.2The clinical management of patients with severe hemophilia A is therefore based upon prevention of bleeding and prompt treatment of bleeds to prevent joint damage.1 Here, F8 is linked to hemophilia A.