EPO and lupus nephritis: Anemic of chronic disease in SLE patients is usually caused by the insufficient production of erythropoietin (Epo) and RBC resistance to Epo; lupus nephritis can cause kidney disease in SLE patients Functional failure, which in turn leads to insufficient Epo and the presence of anti-Epo antibodies.[6] aCL-IgG and/or aCL-IgM are frequently present in immune-related anemia patients, indicating that these antibodies may be in autoantibodies It plays a major role in the pathogenesis of inducing red blood cell destruction.