In the TME, PD-L1 is also widely expressed on immune cells (such as CD4(+) T cells, CD8(+) T cells, Treg cells, B cells, Langerhans cells, and monocytes) and non-immune cells (such as vascular endothelial cells, and various mesenchymal cells) in addition to cancer cells. The gene discussed is CD8A; the disease is cancer.