SPEM1 and Abnormal sperm morphology: The ZMYND15 gene (614312), which located at chromosome 17p13.2, is closely associated with azoospermia.[20] The DNAH2 gene (603333) has been mapped to chromosome 17p13.1, and is related to severe teratozoospermia.[21] The SPEM1 gene to chromosome 17p13.1 is predicted to function in late stages of spermatid maturation.[22] The 3 RCT carriers in this study included 4 breakpoints: 6p21, 10q11.2, 17p13, and 20q13.