Several studies have suggested that this condition may be associated with high levels of circulating insulin cross-reacting with IGF-1 receptors on keratinocytes and dermal fibroblasts.[8] Severe insulin resistance syndromes may manifest as hypertriglyceridemia, abnormal fat morphology, and adipose tissue loss.[9] The patients in this study had normal triglyceride levels. The gene discussed is INS; the disease is hypertriglyceridemia.