SIRT1 and endothelial dysfunction: It was found that resveratrol could effectively improve endothelial dysfunction through SIRT1 and PPARδ signal pathway, and resveratrol increased the transcriptional activity of PPARδ in EC.[34] Sha W et al also found that resveratrol improved human glycated low-density lipoprotein-induced apoptosis, inflammatory factor secretion and oxidative stress of vascular EC by regulating miR-142-3p and sprouty-related EVH1 domain 2-mediated autophagy.[35]