One proposed mechanism is the impact of CB1 and cannabinoid receptor type 2 on platelet expression of glycoprotein IIb-IIIa and P-selectin, which, when coupled with endothelial damage and increases in heart rate and sympathomimetic activity, may precipitate myocardial and peripheral vascular events.[11] There is evidence that cannabis has the potential to trigger myocardial infarction (MI). This evidence concerns the gene SELP and myocardial infarction.