CRS is a systemic inflammatory disease mediated by several cytokines, including IL-6, TNF-α α IFN-γ, IL-2, IL-8, IL-10, and granulocyte-macrophage colony-stimulating factor (GM-CSF), of which IL-6 is considered the main protagonist.[10] Mild cases of CRS are characterized by fever, while severe cases are often characterized by hypotension and multi-organ dysfunction. This evidence concerns the gene TNF and congenital rubella syndrome.