Previous studies have shown that c reactive protein (CRP) is an acute responder to IL-6 stimulation in the liver and that CRP levels can serve as a reliable surrogate for IL-6 bioactivity.[13] CRP is highly expressed in patients with CRS, and the level of CRP can predict the risk of developing severe CRS, and monitoring CRP levels during the development of CRS has clinical significance.[2] In patients with CRS, CRP monitoring can replace cytokine monitoring to some extent because it is quick and inexpensive. This evidence concerns the gene IL6 and congenital rubella syndrome.