It was showed that the potential targets of ursolic acid in the treatment of OP mainly include hepatitis B, TNF signaling pathway, pathways in cancer, human cytomegalovirus infection (HTLV), AGE-RAGE signaling pathway in diabetic complications, IL-17 signaling pathway, apoptosis, human T-cell leukemia virus 1 infection, pancreatic cancer, pathogenic Escherichia coli infection, colorectal cancer, relaxin signaling pathway, prostate cancer, platinum drug resistance and many other pathways. Here, RENBP is linked to escherichia coli infection.