Moreover, low expression of FNDC5 and high expression of FNDC8 were observed in colon adenocarcinoma according to the TIMER database (see Figure S1 e, Supplemental Digital Content, http://links.lww.com/MD/I31) which demonstrates the mRNA expression levels of the FNDC family in human cancers from TIMER). Here, FNDC5 is linked to colon adenocarcinoma.