E2F1 and hepatocellular carcinoma: CASC11 promotes hepatocellular carcinoma growth through EIF4A3 mediated E2F1.[41] Up-regulated LINC00205 is positively correlated with grade and leads to poor prognosis of hepatocellular carcinoma, and LINC00205 knockout promotes cell cycle arrest and apoptosis of tumor cells in G0/G1 phase.