YY1 and cancer: Further rescue tests showed that Karyopherin α 4 overexpression attenuates the inhibitory effect of MCM3AP-AS1 silencing on angiogenesis and progression of lung cancer cells.[15] PKMYT1 is a major player in cell cycle regulation and DNA damage recognition and repair in cancer cells.[16] PKMYT1AR induced by YY1 directly interacts with miR-485-5p to inhibit the expression of oncogene PKMYT1.