lncRNA PVT1 is involved in the progression of various tumors, including non-small cell lung cancer, hepatocellular carcinoma, gastric cancer, breast cancer and glioma.[11] Researchers found that YY1 can directly bind to the promoter region of PVT1 to promote tumor growth in lung cancer.[12] Similar studies have shown that UPLA1 is associated with the progression and prognosis of lung cancer. This evidence concerns the gene YY1 and central nervous system cancer.