PTEN and breast cancer: The up-regulated LINC00152 significantly promoted the ubiquitination and degradation of PTEN protein in breast cancer.[20] YY1 promote the transcription of Kcnq1to1, which mediated PTEN methylation through DNMT1, thereby inhibiting the expression of PTEN in triple negative breast cancer.[21] PTEN is a tumor suppressor gene in breast cancer and is frequently mutated/lost in tumors.[22] miRNA also participates in YY1-regulated lncRNAs network in breast cancer.