With the confirmation of YY1 and lncRNAs as tumor regulatory networks, more and more researchers have conducted further studies on their crosstalk mechanism and found that YY1-regulated lncRNAs are involved in the regulation of esophageal squamous cell carcinoma, laryngeal squamous cell carcinoma, nasopharyngeal carcinoma, cholangiocarcinoma, gastric cancer, bladder cancer, melanoma, prostate cancer, acute leukemia and osteosarcoma. Here, YY1 is linked to esophageal squamous cell carcinoma.