Pancreatic cancer has become the third leading cause of tumor-related death in the United States, and new cases and deaths continue to increase each year.[43] LINC00842 participates in metabolic remodeling in pancreatic cancer cells and is deacetylated by SIRT1 (Sirtuin 1) by inhibiting the acetylation of Peroxisome proliferator-activated receptor-γ coactivator. The gene discussed is SIRT1; the disease is familial pancreatic carcinoma.