This result was achieved mainly by sponging miR-515-5p to act as ceRNA to regulate MARK4 (Microtubule affinity regulating kinase 4) expression and thereby inhibit Hippo signaling pathway.[23] DUXAP8 acts as a miR-29a-3p sponge to promote the expression of the downstream gene SAPCD2 (Suppressor APC Domain Containing 2) in breast cancer. The gene discussed is MARK4; the disease is breast carcinoma.