Glioma is the most common primary tumor of the central nervous system, and about half of gliomas are diagnosed as glioblastoma, a highly aggressive brain tumor.[25] Aging is an important factor associated with poor prognosis of glioblastoma, and YY1 binds to the promoter domain of TP73-AS1 in the aging brain to promote its transcription.[26] YY1 promoted the transcription of SNHG5 in glioblastoma, and it was found that SNHG5 could enhance the carcinogenic role of P38/MAPK signaling pathway in glioblastoma.[27] miRNA also participates in YY1-regulated lncRNAs network in gliomas. The gene discussed is YY1; the disease is brain neoplasm.