ACE2 and neurodegenerative disease: SARS-CoV-2 is a highly neuroinvasive neurotropic virus that invades cells via an angiotensin-converting enzyme 2 (ACE2) receptor-driven pathway.[2] SARS-CoV-2-mediated neuroinvasion, neuroinflammation and blood-brain barrier (BBB) dysfunction may contribute to the development of neurodegenerative diseases (ND).