TLR2 and Norrie disease: tLR2 is also expressed in neurons, and long-term SARS-CoV-2 infection may induce neuronal TLR2 activation in the brain, and induction of neuronal TLR2 is closely associated with transmission and propagation between neurons in pathological alpha syndrome, which is associated with disease progression.[76] Thus, E protein induction of neuronal TLR2 susceptibility by SARS-CoV-2 may lead to deposition of aberrant proteins in cells, thereby affecting COVID-19 episodes and accelerating ND progression.