YY1 and osteosarcoma: hsa-mir-124-3p accelerates the growth and metastasis of osteosarcoma cells,[114] glioma cells,[115] and hepatocellular carcinoma cells.[116] In addition, the TFs FOXC1, GATA2, JUN, YY1, and RELA were found to be overexpressed in common DEGs of ND and COVID-19 This is consistent with previous findings.[117–119] Unfortunately, the development of JNK subtype inhibitors as treatments for neurodegenerative diseases has not been smooth.