ACE2 and pulmonary fibrosis: Glycyrrhizin, the main active component of licorice, has been shown to interact directly with ACE2, thereby blocking the binding of SARS-CoV-2 to ACE-2, and thus licorice may be a potential drug for the treatment of COVID-19.[44,45] In addition, licorice has better anti-inflammatory, antiviral, antibacterial, immunomodulatory, and anti-pulmonary fibrosis advantages.[46] This further reflects the fact that licorice is used in the treatment of neocon of the importance and necessity of its presence in almost all prescriptions.