SENP8 and neoplasm: Not surprisingly, multiplex IHC (mIHC) validated more profound pERK inhibition as well as increased cleaved caspase-3 signal in tumors from Senp8mφ–/– mice under anti-PDL1 treatment (Figure 9E and Supplemental Figure 6D), and SENP8 deficiency promoted M1 polarization of TIMs in tumor infiltrates (Supplemental Figure 6E).