To directly test the immune cell–specific role of miR-33, we generated myeloid-specific miR-33–KO mice (LysMCRE+miR-33LOX/LOX [miR-33M/M–/–] and appropriate controls LysMCRE–miR-33LOX/LOX [miR-33M/M+/+]) and subjected them to a bleomycin-induced PF model. Here, LOX is linked to pemphigus foliaceus.