Significant correlations between mechanical power of ventilation and levels of TGF-β1 in patients with acute respiratory distress syndrome are evident (82) Neonatal mice exposed to 24 h of mechanical ventilation exhibited a stretch-induced increase in TGF-β activation and a dramatic increase in the TGF-β signaling protein pSmad2 protein in the lungs (78, 80). The gene discussed is TGFB1; the disease is acute respiratory distress syndrome.