In addition, pathogenic gene variants of two signaling molecules that regulate NF-κB, namely TNF interacting protein 2, and TNF receptor associated factor 2 are implicated in the development of PAH (Pienkos et al., 2021), and the inhibition of the NF-κB signaling cascade has a therapeutic effect on PH (Hosokawa et al., 2013; Li et al., 2014). Here, NFKB1 is linked to pulmonary arterial hypertension.